Limited heterogeneity of T cell receptor BV usage in aplastic anemia. Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the Vβ17 gene segment. The many important facets of T-cell repertoire diversity. Size estimate of the αβTCR repertoire of naive mouse splenocytes. A direct estimate of the human αβT cell receptor diversity. Quantitative analysis of the CD8 + T-cell response to readily eliminated and persistent viruses. T-cell antigen receptor genes and T-cell recognition. Engineered T cell receptors and their potential in molecular medicine. Structural determinants of T-cell receptor bias in immunity. Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection. Molecular TCR diagnostics can be used to identify shared clonotypes after allogeneic hematopoietic stem cell transplantation. Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove. A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE. T cell repertoire diversity is required for relapses in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Persistence of autoreactive myelin oligodendrocyte glycoprotein (MOG)-specific T cell repertoires in MOG-expressing mice. The T cell repertoire in infection and vaccination: implications for control of persistent viruses. T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. Strong TCR conservation and altered T cell cross-reactivity characterize a B*57-restricted immune response in HIV-1 infection. Rapid CD8 + T cell repertoire focusing and selection of high-affinity clones into memory following primary infection with a persistent human virus: human cytomegalovirus. Predictable αβT-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope. Selection of T cell clones expressing high-affinity public TCRs within human cytomegalovirus-specific CD8 T cell responses. Avidity for antigen shapes clonal dominance in CD8 + T cell populations specific for persistent DNA viruses. Dominant TCR Vα usage by virus and tumor-reactive T cells with wide affinity ranges for their specific antigens. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. Comparative analysis of CD8 + T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotype. Frequent contribution of T cell clonotypes with public TCR features to the chronic response against a dominant EBV-derived epitope: application to direct detection of their molecular imprint on the human peripheral T cell repertoire. Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein–Barr virus. A structural basis for the selection of dominant αβ T cell receptors in antiviral immunity. The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and a mode of MHC class I dimerization. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. TCRα genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope. The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Implications for T-cell receptor engagement and T-cell immunodominance. High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class, I. CTL recognition of a bulged viral peptide involves biased TCR selection. Private specificities of CD8 T cell responses control patterns of heterologous immunity. Public and private VβT cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice.
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